ABSTRACT
Objective To study the effect of elective single blastocyst transfer (eSBT) on the pregnancy outcome of women undergoing in vitro fertilization and embryo transplantation (IVF-ET). Methods A perspective study on eSBT was conducted from March 2007 to December 2011. The patients were divided into three groups based on embryonic development and number of embryos transplanted: group A, single blastocyst transfer (n=287); group B, two blastocysts transfer (n=53); group C, cleavage stage embryo transfer (n=382). The difference in clinical data, laboratory data and pregnancy outcome were compared among the three groups. Patients from group A and B who achieved to have at least two good blastocysts were reviewed, and divided into twice single blastocyst transfer (T-SBT) group and once two blastocysts transfer (O-DBT) group. With the cumulative transplantation of two blastocysts serving as an example, the pregnancy rate and cumulative pregnancy rate were compared between the T-SBT group and O-DBT group. Results The clinical pregnancy rate in single transplantation cycle decreased significantly in group A compared with that of group B (P0.05), but the implantation rate was increased and multiple pregnancy rate was lower significantly in group A (P0.05). Conclusion Compared with two blastocysts transfer and cleavage stage embryo transfer, elective single blastocyst transfer may obviously decrease the multiple pregnancy rate and OHSS rate, therefore it is suitable to apply in some of patients who meet the criteria.
ABSTRACT
Objective To study the effect of elective single blastocyst transfer (eSBT) on the pregnancy outcome of women undergoing in vitro fertilization and embryo transplantation (IVF-ET). Methods A perspective study on eSBT was conducted from March 2007 to December 2011. The patients were divided into three groups based on embryonic development and number of embryos transplanted: group A, single blastocyst transfer (n=287); group B, two blastocysts transfer (n=53); group C, cleavage stage embryo transfer (n=382). The difference in clinical data, laboratory data and pregnancy outcome were compared among the three groups. Patients from group A and B who achieved to have at least two good blastocysts were reviewed, and divided into twice single blastocyst transfer (T-SBT) group and once two blastocysts transfer (O-DBT) group. With the cumulative transplantation of two blastocysts serving as an example, the pregnancy rate and cumulative pregnancy rate were compared between the T-SBT group and O-DBT group. Results The clinical pregnancy rate in single transplantation cycle decreased significantly in group A compared with that of group B (P0.05), but the implantation rate was increased and multiple pregnancy rate was lower significantly in group A (P0.05). Conclusion Compared with two blastocysts transfer and cleavage stage embryo transfer, elective single blastocyst transfer may obviously decrease the multiple pregnancy rate and OHSS rate, therefore it is suitable to apply in some of patients who meet the criteria.
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA).</p><p><b>METHODS</b>Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group).</p><p><b>RESULTS</b>The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05).</p><p><b>CONCLUSION</b>There is a relationship between sperm DNA damage and URSA.</p>